MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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Ratio	neuronal	p	description	Accession

Results: HTML CSV LaTeX

Showing element 191 to 239 of 239 in total

Ratio  : up

neuronal	p	description
no value	0.0395988	intercellular junction maintenance
		iron-sulfur cluster binding
		mannosidase activity
		methylated-DNA-[protein]-cysteine S-methyltransferase activity
		mitochondrial small ribosomal subunit
		mitotic G2 checkpoint
		monoamine transport
		myoblast fusion
		nuclear organization and biogenesis
		orexin receptor activity
		oxidized purine base lesion DNA N-glycosylase activity
		peroxisome organization and biogenesis
		phosphatidylinositol N-acetylglucosaminyltransferase activity
		phosphoinositide-mediated signaling
		positive regulation of meiosis
		positive regulation of mitosis
		positive regulation of viral genome replication
		prostaglandin-endoperoxide synthase activity
		protein amino acid lipidation
		protein phosphatase type 1 complex
		regulation of cyclin-dependent protein kinase activity
		regulation of inflammatory response
		response to cold
		response to sterol depletion
		retinoic acid receptor signaling pathway
		STAT protein nuclear translocation
		Toll binding
	0.0402868	protein amino acid dephosphorylation
	0.0404804	amino acid metabolic process
	0.0431445	metal ion binding
	0.0470779	transcriptional activator activity
	0.0473076	calcium channel activity
	0.0483241	chromatin binding
	0.0493456	cell growth
1	0.00115531	neuropeptide hormone activity
	0.00564318	dopamine receptor activity
	0.00670433	voltage-gated ion channel activity
	0.00774091	electron carrier activity
	0.00878703	nervous system development
	0.00916333	visual perception
	0.0100316	potassium ion binding
	0.0159483	sensory perception of sound
	0.0202076	detection of stimulus during sensory perception
	0.0262113	neurotransmitter:sodium symporter activity
	0.0280274	synapse
	0.02908	calcium channel regulator activity
	0.0395988	axon ensheathment
		cannabinoid receptor activity
		neuropeptide receptor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.