MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
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description	p	Accession	neuronal	Ratio

Results: HTML CSV LaTeX

Showing element 91 to 140 of 239 in total

description	p	neuronal	Ratio
inner ear morphogenesis	0.0340565	no value	up
inorganic anion exchanger activity	0.0368141
integral to Golgi membrane	0.0254395
integral to membrane	0.000000909018		down
integral to peroxisomal membrane	0.0395988		up
integral to plasma membrane	0.0000520983
integrase activity	0.028596		down
intercellular junction maintenance	0.0395988		up
interleukin-1 receptor activity	0.00383965
interleukin-1 receptor complex	0.0202076
interleukin-18 receptor complex
intracellular	0.00836988
iron-sulfur cluster binding	0.0395988
kinase activity	0.0216681		down
leading edge cell differentiation	0.0202076		up
leukocyte activation
leukocyte adhesion
ligand-dependent nuclear receptor activity	0.00564318
lipid biosynthetic process	0.0156029
lipid metabolic process	0.0354267
male pronucleus	0.0202076
mannosidase activity	0.0395988
membrane	0
membrane coat	0.00383965
membrane fraction	0.0000321095
metabolic process	0.0193082
metabotropic glutamate receptor signaling pathway	0.00362499	1	down
metabotropic glutamate, GABA-B-like receptor activity	0.0111584
metal ion binding	0.0431445	no value	up
metallopeptidase activity	0.0193329
methyl-CpG binding	0.0202076
methylated-DNA-[protein]-cysteine S-methyltransferase activity	0.0395988
microtubule binding	0.0107462
microtubule-based movement	0.0206183		down
mitochondrial small ribosomal subunit	0.0395988		up
mitochondrion	0.00965867		down
mitosis	0.00504034		up
mitotic G2 checkpoint	0.0395988
monoamine transport
monoamine transporter activity	0.0202076
morphogenesis of an epithelium	0.0127396
mRNA transport	0.000408197
multicellular organismal development	0.00726676
myoblast fusion	0.0395988
NAD binding	0.00245746		down
negative regulation of cell growth	0.00664368		up
negative regulation of protein kinase activity	0.0368141
nervous system development	0.00878703	1
neuropeptide hormone activity	0.00115531
neuropeptide receptor activity	0.0395988

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.