MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

p	neuronal	description	Ratio	Accession

Results: HTML CSV LaTeX

Showing element 72 to 121 of 239 in total

p	neuronal	description	Ratio
0.00614065	no value	RNA polymerase II transcription factor activity	up
0.00664368		negative regulation of cell growth
0.00670433	1	voltage-gated ion channel activity
0.00718696	no value	regulation of transcription, DNA-dependent	down
0.00726676		multicellular organismal development	up
0.00759448		protein serine/threonine phosphatase activity
0.00774091		acetyltransferase activity
		ER-Golgi intermediate compartment
		guanyl nucleotide binding
		positive regulation of body size
		retinoic acid metabolic process
	1	electron carrier activity
0.00803044	no value	binding	down
0.00833399		regulation of transcription	up
0.00836988		intracellular
0.00878703	1	nervous system development
0.00916333		visual perception
0.00965867	no value	mitochondrion	down
0.00970846		chromosome, pericentric region	up
0.0100316	1	potassium ion binding
0.0101128	no value	anatomical structure morphogenesis
		humoral immune response
0.0105006		trypsin activity	down
0.0107462		microtubule binding	up
0.01078		Golgi stack	down
0.0108714		nucleoplasm	up
0.0109032		endoplasmic reticulum
0.0109353		calmodulin binding
0.0111584	1	metabotropic glutamate, GABA-B-like receptor activity	down
0.011406	no value	cell proliferation	up
0.0126107		positive regulation of cell proliferation
0.0127396		fibroblast growth factor receptor signaling pathway
		glycerophosphodiester phosphodiesterase activity
		morphogenesis of an epithelium
		sodium:dicarboxylate symporter activity
0.0148187		protein transport
0.0156029		dicarboxylic acid transport
		lipid biosynthetic process
0.0159483	1	sensory perception of sound
0.0168307	no value	protein modification process
0.0175073		chymotrypsin activity	down
0.0189449		electron transport
0.0189851		response to oxidative stress	up
0.0192954		cell motility
		extracellular matrix
0.0193082		metabolic process
0.0193329		metallopeptidase activity
0.0197922	1	sensory perception	down
0.0202076	no value	AP-2 adaptor complex	up
		ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.