MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

description	Accession	p	neuronal	Ratio

Results: HTML CSV LaTeX

Showing element 72 to 121 of 239 in total

description	p	neuronal	Ratio
generation of precursor metabolites and energy	0.0395988	no value	up
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	0.0040154		down
glycerol metabolic process	0.000857538		up
glycerophosphodiester phosphodiesterase activity	0.0127396
glycolysis	0.00369746		down
glycosaminoglycan binding	0.0395988		up
glyoxylate cycle	0.0202076
Golgi apparatus	0.0000000750539
Golgi stack	0.01078		down
growth hormone secretion	0.0395988		up
GTPase activity	0.000793622
guanyl nucleotide binding	0.00774091
hemostasis	0.0395988
histamine receptor activity	0.00383965
homoiothermy	0
hormone activity	0.023627
humoral immune response	0.0101128
ice binding	0
identical protein binding	0.00308834
inner ear morphogenesis	0.0340565
inorganic anion exchanger activity	0.0368141
integral to Golgi membrane	0.0254395
integral to membrane	0.000000909018		down
integral to peroxisomal membrane	0.0395988		up
integral to plasma membrane	0.0000520983
integrase activity	0.028596		down
intercellular junction maintenance	0.0395988		up
interleukin-1 receptor activity	0.00383965
interleukin-1 receptor complex	0.0202076
interleukin-18 receptor complex
intracellular	0.00836988
iron-sulfur cluster binding	0.0395988
kinase activity	0.0216681		down
leading edge cell differentiation	0.0202076		up
leukocyte activation
leukocyte adhesion
ligand-dependent nuclear receptor activity	0.00564318
lipid biosynthetic process	0.0156029
lipid metabolic process	0.0354267
male pronucleus	0.0202076
mannosidase activity	0.0395988
membrane	0
membrane coat	0.00383965
membrane fraction	0.0000321095
metabolic process	0.0193082
metabotropic glutamate receptor signaling pathway	0.00362499	1	down
metabotropic glutamate, GABA-B-like receptor activity	0.0111584
metal ion binding	0.0431445	no value	up
metallopeptidase activity	0.0193329
methyl-CpG binding	0.0202076

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.