MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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p	Ratio	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 22 to 71 of 239 in total

p	Ratio	description	neuronal
0.00000144966	down	nucleic acid binding	no value
0.00000618855		translation
0.00000824263	up	structural constituent of cell wall
0.0000171601		protein kinase activity
0.0000189325		phosphoric monoester hydrolase activity
0.0000244289		cell-cell signaling
0.0000251477	down	ribosome
0.0000321095	up	membrane fraction
0.0000325409	down	G-protein coupled receptor protein signaling pathway
0.0000520983	up	integral to plasma membrane
0.0000603978	down	protein ubiquitination
0.0000791323	up	protein C-terminus binding
0.000237102		nucleocytoplasmic transport
0.00038871	down	external side of plasma membrane
0.000408197	up	flagellin-based flagellum
		mRNA transport
0.000541705	down	ubiquitin ligase complex
0.000654237		zinc ion binding
0.000762333	up	protein dimerization activity
0.000793622		GTPase activity
0.000857538		glycerol metabolic process
0.000975592		transcription
0.00115531		neuropeptide hormone activity	1
0.00123417	down	ATP binding	no value
0.00127674		antigen binding
0.00141209	up	extracellular region
0.00235127		anion exchanger activity
		arylamine N-acetyltransferase activity
		ciliary or flagellar motility
0.00245746	down	NAD binding
0.0025796	up	positive regulation of transcription
		regulation of transcription from RNA polymerase II promoter
0.00273397	down	ubiquitin-protein ligase activity
0.00308834	up	identical protein binding
0.00356939		signal transduction
0.00362499	down	metabotropic glutamate receptor signaling pathway	1
0.00369746		glycolysis	no value
0.00383965	up	aldehyde dehydrogenase [NAD(P)+] activity
		histamine receptor activity
		interleukin-1 receptor activity
		membrane coat
		nucleoside transporter activity
0.00391116		soluble fraction
0.0040154	down	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
0.00425207	up	cell cycle
0.00504034		mitosis
0.00564318		circulation
		dopamine receptor activity	1
		ligand-dependent nuclear receptor activity	no value
		positive regulation of I-kappaB kinase/NF-kappaB cascade

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.