MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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neuronal	Ratio	Accession	description	p

Results: HTML CSV LaTeX

Showing element 191 to 239 of 239 in total

neuronal	Ratio	description	p
no value	up	response to drug	0.0254395
		response to freezing	0
		response to oxidative stress	0.0189851
		response to sterol depletion	0.0395988
		response to stimulus	0
		retinoic acid metabolic process	0.00774091
		retinoic acid receptor signaling pathway	0.0395988
		ribonuclease activity	0.0328763
		RNA lariat debranching enzyme activity	0.0202076
		RNA polymerase II transcription factor activity	0.00614065
		RNA splicing	0.0000000131078
		selenocysteine incorporation	0.0202076
		signal transduction	0.00356939
		small conjugating protein ligase activity	0
		sodium:dicarboxylate symporter activity	0.0127396
		soluble fraction	0.00391116
		STAT protein nuclear translocation	0.0395988
		structural constituent of cell wall	0.00000824263
		Toll binding	0.0395988
		transcription	0.000975592
		transcription cofactor activity	0.0254395
		transcription factor activity	0.0374953
		transcription from RNA polymerase II promoter	0.0382916
		transcription from RNA polymerase III promoter	0.0202076
		transcriptional activator activity	0.0470779
		transport vesicle	0.0202076
		tyrosine phosphorylation of STAT protein
		ubiquitin cycle	0.0335097
		vitamin D receptor binding	0.0202076
		zygotic determination of anterior/posterior axis, embryo
1	down	metabotropic glutamate receptor signaling pathway	0.00362499
		metabotropic glutamate, GABA-B-like receptor activity	0.0111584
		olfactory receptor activity	0.000000227862
		sensory perception	0.0197922
	up	axon ensheathment	0.0395988
		calcium channel regulator activity	0.02908
		cannabinoid receptor activity	0.0395988
		detection of stimulus during sensory perception	0.0202076
		dopamine receptor activity	0.00564318
		electron carrier activity	0.00774091
		nervous system development	0.00878703
		neuropeptide hormone activity	0.00115531
		neuropeptide receptor activity	0.0395988
		neurotransmitter:sodium symporter activity	0.0262113
		potassium ion binding	0.0100316
		sensory perception of sound	0.0159483
		synapse	0.0280274
		visual perception	0.00916333
		voltage-gated ion channel activity	0.00670433

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.