MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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neuronal	description	p	Accession	Ratio

Results: HTML CSV LaTeX

Showing element 151 to 200 of 239 in total

neuronal  : no value

description	p	Ratio
positive regulation of mitosis	0.0395988	up
positive regulation of receptor mediated endocytosis	0.0202076
positive regulation of smooth muscle contraction
positive regulation of transcription	0.0025796
positive regulation of vasoconstriction	0.0202076
positive regulation of viral genome replication	0.0395988
prostaglandin-endoperoxide synthase activity
protein amino acid dephosphorylation	0.0402868
protein amino acid lipidation	0.0395988
protein binding	0
protein C-terminus binding	0.0000791323
protein complex assembly	0.024391
protein dimerization activity	0.000762333
protein homodimerization activity	0.0338741
protein kinase activity	0.0000171601
protein kinase C inhibitor activity	0.0202076
protein modification process	0.0168307
protein phosphatase type 1 complex	0.0395988
protein phosphatase type 2A activity	0.0202076
protein serine/threonine phosphatase activity	0.00759448
protein transport	0.0148187
protein ubiquitination	0.0000603978	down
proteolysis	0.0204393
receptor activity	0.0000000000369233
regulation of cyclin-dependent protein kinase activity	0.0395988	up
regulation of inflammatory response
regulation of progression through cell cycle	0.00000117775
regulation of transcription	0.00833399
regulation of transcription from RNA polymerase II promoter	0.0025796
regulation of transcription, DNA-dependent	0.00718696	down
regulation of viral transcription	0.0202076	up
response to cold	0.0395988
response to drug	0.0254395
response to freezing	0
response to oxidative stress	0.0189851
response to sterol depletion	0.0395988
response to stimulus	0
retinoic acid metabolic process	0.00774091
retinoic acid receptor signaling pathway	0.0395988
ribonuclease activity	0.0328763
ribosome	0.0000251477	down
RNA lariat debranching enzyme activity	0.0202076	up
RNA polymerase II transcription factor activity	0.00614065
RNA splicing	0.0000000131078
selenocysteine incorporation	0.0202076
signal transduction	0.00356939
small conjugating protein ligase activity	0
sodium:dicarboxylate symporter activity	0.0127396
soluble fraction	0.00391116
STAT protein nuclear translocation	0.0395988

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.