MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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Ratio	description	Accession	p	neuronal

Results: HTML CSV LaTeX

Showing element 141 to 190 of 239 in total

Ratio  : up

description	p	neuronal
methylated-DNA-[protein]-cysteine S-methyltransferase activity	0.0395988	no value
microtubule binding	0.0107462
mitochondrial small ribosomal subunit	0.0395988
mitosis	0.00504034
mitotic G2 checkpoint	0.0395988
monoamine transport
monoamine transporter activity	0.0202076
morphogenesis of an epithelium	0.0127396
mRNA transport	0.000408197
multicellular organismal development	0.00726676
myoblast fusion	0.0395988
negative regulation of cell growth	0.00664368
negative regulation of protein kinase activity	0.0368141
nervous system development	0.00878703	1
neuropeptide hormone activity	0.00115531
neuropeptide receptor activity	0.0395988
neurotransmitter:sodium symporter activity	0.0262113
nuclear organization and biogenesis	0.0395988	no value
nucleocytoplasmic transport	0.000237102
nucleoplasm	0.0108714
nucleoside transporter activity	0.00383965
nucleotide binding	0.0322278
oocyte differentiation	0.0202076
orexin receptor activity	0.0395988
osmosensory signaling pathway	0.0202076
oxidized purine base lesion DNA N-glycosylase activity	0.0395988
peroxisome organization and biogenesis
phosphatidylinositol N-acetylglucosaminyltransferase activity
phosphatidylinositol-3,4,5-triphosphate binding	0.0202076
phosphoinositide-mediated signaling	0.0395988
phosphoric monoester hydrolase activity	0.0000189325
plasma membrane	0.037387
positive regulation of body size	0.00774091
positive regulation of cell proliferation	0.0126107
positive regulation of I-kappaB kinase/NF-kappaB cascade	0.00564318
positive regulation of meiosis	0.0395988
positive regulation of mitosis
positive regulation of receptor mediated endocytosis	0.0202076
positive regulation of smooth muscle contraction
positive regulation of transcription	0.0025796
positive regulation of vasoconstriction	0.0202076
positive regulation of viral genome replication	0.0395988
potassium ion binding	0.0100316	1
prostaglandin-endoperoxide synthase activity	0.0395988	no value
protein amino acid dephosphorylation	0.0402868
protein amino acid lipidation	0.0395988
protein binding	0
protein C-terminus binding	0.0000791323
protein complex assembly	0.024391
protein dimerization activity	0.000762333

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.