MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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Accession	description	p	Ratio	neuronal

Results: HTML CSV LaTeX

Showing element 141 to 190 of 239 in total

description	p	Ratio	neuronal
neurotransmitter:sodium symporter activity	0.0262113	up	1
nuclear organization and biogenesis	0.0395988		no value
nucleic acid binding	0.00000144966	down
nucleocytoplasmic transport	0.000237102	up
nucleoplasm	0.0108714
nucleoside transporter activity	0.00383965
nucleotide binding	0.0322278
nucleus	0	down
olfactory receptor activity	0.000000227862		1
oocyte differentiation	0.0202076	up	no value
orexin receptor activity	0.0395988
osmosensory signaling pathway	0.0202076
oxidized purine base lesion DNA N-glycosylase activity	0.0395988
peroxisome organization and biogenesis
phosphatidylinositol N-acetylglucosaminyltransferase activity
phosphatidylinositol-3,4,5-triphosphate binding	0.0202076
phosphoinositide-mediated signaling	0.0395988
phosphoric monoester hydrolase activity	0.0000189325
plasma membrane	0.037387
positive regulation of body size	0.00774091
positive regulation of cell proliferation	0.0126107
positive regulation of I-kappaB kinase/NF-kappaB cascade	0.00564318
positive regulation of meiosis	0.0395988
positive regulation of mitosis
positive regulation of receptor mediated endocytosis	0.0202076
positive regulation of smooth muscle contraction
positive regulation of transcription	0.0025796
positive regulation of vasoconstriction	0.0202076
positive regulation of viral genome replication	0.0395988
potassium ion binding	0.0100316		1
prostaglandin-endoperoxide synthase activity	0.0395988		no value
protein amino acid dephosphorylation	0.0402868
protein amino acid lipidation	0.0395988
protein binding	0
protein C-terminus binding	0.0000791323
protein complex assembly	0.024391
protein dimerization activity	0.000762333
protein homodimerization activity	0.0338741
protein kinase activity	0.0000171601
protein kinase C inhibitor activity	0.0202076
protein modification process	0.0168307
protein phosphatase type 1 complex	0.0395988
protein phosphatase type 2A activity	0.0202076
protein serine/threonine phosphatase activity	0.00759448
protein transport	0.0148187
protein ubiquitination	0.0000603978	down
proteolysis	0.0204393
receptor activity	0.0000000000369233
regulation of cyclin-dependent protein kinase activity	0.0395988	up
regulation of inflammatory response

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.