MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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neuronal	description	Ratio	p	Accession

Results: HTML CSV LaTeX

Showing element 101 to 150 of 239 in total

neuronal  : no value

description	Ratio	p
leukocyte adhesion	up	0.0202076
ligand-dependent nuclear receptor activity		0.00564318
lipid biosynthetic process		0.0156029
lipid metabolic process		0.0354267
male pronucleus		0.0202076
mannosidase activity		0.0395988
membrane		0
membrane coat		0.00383965
membrane fraction		0.0000321095
metabolic process		0.0193082
metal ion binding		0.0431445
metallopeptidase activity		0.0193329
methyl-CpG binding		0.0202076
methylated-DNA-[protein]-cysteine S-methyltransferase activity		0.0395988
microtubule binding		0.0107462
microtubule-based movement	down	0.0206183
mitochondrial small ribosomal subunit	up	0.0395988
mitochondrion	down	0.00965867
mitosis	up	0.00504034
mitotic G2 checkpoint		0.0395988
monoamine transport
monoamine transporter activity		0.0202076
morphogenesis of an epithelium		0.0127396
mRNA transport		0.000408197
multicellular organismal development		0.00726676
myoblast fusion		0.0395988
NAD binding	down	0.00245746
negative regulation of cell growth	up	0.00664368
negative regulation of protein kinase activity		0.0368141
nuclear organization and biogenesis		0.0395988
nucleic acid binding	down	0.00000144966
nucleocytoplasmic transport	up	0.000237102
nucleoplasm		0.0108714
nucleoside transporter activity		0.00383965
nucleotide binding		0.0322278
nucleus	down	0
oocyte differentiation	up	0.0202076
orexin receptor activity		0.0395988
osmosensory signaling pathway		0.0202076
oxidized purine base lesion DNA N-glycosylase activity		0.0395988
peroxisome organization and biogenesis
phosphatidylinositol N-acetylglucosaminyltransferase activity
phosphatidylinositol-3,4,5-triphosphate binding		0.0202076
phosphoinositide-mediated signaling		0.0395988
phosphoric monoester hydrolase activity		0.0000189325
plasma membrane		0.037387
positive regulation of body size		0.00774091
positive regulation of cell proliferation		0.0126107
positive regulation of I-kappaB kinase/NF-kappaB cascade		0.00564318
positive regulation of meiosis		0.0395988

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.