MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

p	Ratio	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 72 to 121 of 239 in total

p	Ratio	description	neuronal
0.00614065	up	RNA polymerase II transcription factor activity	no value
0.00664368		negative regulation of cell growth
0.00670433		voltage-gated ion channel activity	1
0.00718696	down	regulation of transcription, DNA-dependent	no value
0.00726676	up	multicellular organismal development
0.00759448		protein serine/threonine phosphatase activity
0.00774091		acetyltransferase activity
		electron carrier activity	1
		ER-Golgi intermediate compartment	no value
		guanyl nucleotide binding
		positive regulation of body size
		retinoic acid metabolic process
0.00803044	down	binding
0.00833399	up	regulation of transcription
0.00836988		intracellular
0.00878703		nervous system development	1
0.00916333		visual perception
0.00965867	down	mitochondrion	no value
0.00970846	up	chromosome, pericentric region
0.0100316		potassium ion binding	1
0.0101128		anatomical structure morphogenesis	no value
		humoral immune response
0.0105006	down	trypsin activity
0.0107462	up	microtubule binding
0.01078	down	Golgi stack
0.0108714	up	nucleoplasm
0.0109032		endoplasmic reticulum
0.0109353		calmodulin binding
0.0111584	down	metabotropic glutamate, GABA-B-like receptor activity	1
0.011406	up	cell proliferation	no value
0.0126107		positive regulation of cell proliferation
0.0127396		fibroblast growth factor receptor signaling pathway
		glycerophosphodiester phosphodiesterase activity
		morphogenesis of an epithelium
		sodium:dicarboxylate symporter activity
0.0148187		protein transport
0.0156029		dicarboxylic acid transport
		lipid biosynthetic process
0.0159483		sensory perception of sound	1
0.0168307		protein modification process	no value
0.0175073	down	chymotrypsin activity
0.0189449		electron transport
0.0189851	up	response to oxidative stress
0.0192954		cell motility
		extracellular matrix
0.0193082		metabolic process
0.0193329		metallopeptidase activity
0.0197922	down	sensory perception	1
0.0202076	up	AP-2 adaptor complex	no value
		ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.