MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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p	Ratio	description	neuronal	Accession

Results: HTML CSV LaTeX

Showing element 91 to 140 of 239 in total

p	Ratio	description	neuronal
0.0100316	up	potassium ion binding	1
0.0101128		anatomical structure morphogenesis	no value
		humoral immune response
0.0105006	down	trypsin activity
0.0107462	up	microtubule binding
0.01078	down	Golgi stack
0.0108714	up	nucleoplasm
0.0109032		endoplasmic reticulum
0.0109353		calmodulin binding
0.0111584	down	metabotropic glutamate, GABA-B-like receptor activity	1
0.011406	up	cell proliferation	no value
0.0126107		positive regulation of cell proliferation
0.0127396		fibroblast growth factor receptor signaling pathway
		glycerophosphodiester phosphodiesterase activity
		morphogenesis of an epithelium
		sodium:dicarboxylate symporter activity
0.0148187		protein transport
0.0156029		dicarboxylic acid transport
		lipid biosynthetic process
0.0159483		sensory perception of sound	1
0.0168307		protein modification process	no value
0.0175073	down	chymotrypsin activity
0.0189449		electron transport
0.0189851	up	response to oxidative stress
0.0192954		cell motility
		extracellular matrix
0.0193082		metabolic process
0.0193329		metallopeptidase activity
0.0197922	down	sensory perception	1
0.0202076	up	AP-2 adaptor complex	no value
		ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
		beta-galactoside alpha-2,3-sialyltransferase activity
		beta-mannosidase activity
		camera-type eye development
		carotenoid biosynthetic process
		CD40 receptor binding
		centrosome duplication
		clathrin binding
		cytoplasmic chromatin
		cytoskeletal anchoring
		delayed rectifier potassium channel activity
		detection of stimulus during sensory perception	1
		endodeoxyribonuclease activity	no value
		extracellular matrix binding
		glyoxylate cycle
		interleukin-1 receptor complex
		interleukin-18 receptor complex
		leading edge cell differentiation
		leukocyte activation
		leukocyte adhesion

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.