MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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Ratio	p	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 72 to 121 of 239 in total

Ratio  : up

p	description	neuronal
0.0025796	positive regulation of transcription	no value
	regulation of transcription from RNA polymerase II promoter
0.00308834	identical protein binding
0.00356939	signal transduction
0.00383965	aldehyde dehydrogenase [NAD(P)+] activity
	histamine receptor activity
	interleukin-1 receptor activity
	membrane coat
	nucleoside transporter activity
0.00391116	soluble fraction
0.00425207	cell cycle
0.00504034	mitosis
0.00564318	circulation
	dopamine receptor activity	1
	ligand-dependent nuclear receptor activity	no value
	positive regulation of I-kappaB kinase/NF-kappaB cascade
0.00614065	RNA polymerase II transcription factor activity
0.00664368	negative regulation of cell growth
0.00670433	voltage-gated ion channel activity	1
0.00726676	multicellular organismal development	no value
0.00759448	protein serine/threonine phosphatase activity
0.00774091	acetyltransferase activity
	electron carrier activity	1
	ER-Golgi intermediate compartment	no value
	guanyl nucleotide binding
	positive regulation of body size
	retinoic acid metabolic process
0.00833399	regulation of transcription
0.00836988	intracellular
0.00878703	nervous system development	1
0.00916333	visual perception
0.00970846	chromosome, pericentric region	no value
0.0100316	potassium ion binding	1
0.0101128	anatomical structure morphogenesis	no value
	humoral immune response
0.0107462	microtubule binding
0.0108714	nucleoplasm
0.0109032	endoplasmic reticulum
0.0109353	calmodulin binding
0.011406	cell proliferation
0.0126107	positive regulation of cell proliferation
0.0127396	fibroblast growth factor receptor signaling pathway
	glycerophosphodiester phosphodiesterase activity
	morphogenesis of an epithelium
	sodium:dicarboxylate symporter activity
0.0148187	protein transport
0.0156029	dicarboxylic acid transport
	lipid biosynthetic process
0.0159483	sensory perception of sound	1
0.0168307	protein modification process	no value

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.