MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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Ratio	description	p	neuronal	Accession

Results: HTML CSV LaTeX

Showing element 22 to 71 of 239 in total

Ratio	description	p	neuronal
down	NAD binding	0.00245746	no value
	nucleic acid binding	0.00000144966
	nucleus	0
	olfactory receptor activity	0.000000227862	1
	protein ubiquitination	0.0000603978	no value
	proteolysis	0.0204393
	receptor activity	0.0000000000369233
	regulation of transcription, DNA-dependent	0.00718696
	ribosome	0.0000251477
	sensory perception	0.0197922	1
	structural constituent of ribosome	0.000000819712	no value
	transferase activity	0.0377184
	translation	0.00000618855
	trypsin activity	0.0105006
	ubiquitin ligase complex	0.000541705
	ubiquitin-protein ligase activity	0.00273397
	zinc ion binding	0.000654237
up	7S RNA binding	0.0395988
	acetyltransferase activity	0.00774091
	activation of MAPKK activity	0.0395988
	adult heart development
	aldehyde dehydrogenase [NAD(P)+] activity	0.00383965
	amino acid metabolic process	0.0404804
	anatomical structure morphogenesis	0.0101128
	anion exchanger activity	0.00235127
	anion transport	0.0262113
	antiporter activity	0.0368141
	AP-2 adaptor complex	0.0202076
	apical junction complex	0.0395988
	arylamine N-acetyltransferase activity	0.00235127
	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	0.0202076
	axon ensheathment	0.0395988	1
	beta-galactoside alpha-2,3-sialyltransferase activity	0.0202076	no value
	beta-mannosidase activity
	calcium channel activity	0.0473076
	calcium channel regulator activity	0.02908	1
	calmodulin binding	0.0109353	no value
	camera-type eye development	0.0202076
	cannabinoid receptor activity	0.0395988	1
	carotenoid biosynthetic process	0.0202076	no value
	CD40 receptor binding
	cell adhesion	0.0369324
	cell cycle	0.00425207
	cell growth	0.0493456
	cell junction	0.000000005351
	cell motility	0.0192954
	cell proliferation	0.011406
	cell-cell signaling	0.0000244289
	cellular protein metabolic process	0.0395988
	centrosome duplication	0.0202076

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.