MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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Ratio	description	p	neuronal	Accession

Results: HTML CSV LaTeX

Showing element 172 to 221 of 239 in total

Ratio  : up

description	p	neuronal
plasma membrane	0.037387	no value
positive regulation of body size	0.00774091
positive regulation of cell proliferation	0.0126107
positive regulation of I-kappaB kinase/NF-kappaB cascade	0.00564318
positive regulation of meiosis	0.0395988
positive regulation of mitosis
positive regulation of receptor mediated endocytosis	0.0202076
positive regulation of smooth muscle contraction
positive regulation of transcription	0.0025796
positive regulation of vasoconstriction	0.0202076
positive regulation of viral genome replication	0.0395988
potassium ion binding	0.0100316	1
prostaglandin-endoperoxide synthase activity	0.0395988	no value
protein amino acid dephosphorylation	0.0402868
protein amino acid lipidation	0.0395988
protein binding	0
protein C-terminus binding	0.0000791323
protein complex assembly	0.024391
protein dimerization activity	0.000762333
protein homodimerization activity	0.0338741
protein kinase activity	0.0000171601
protein kinase C inhibitor activity	0.0202076
protein modification process	0.0168307
protein phosphatase type 1 complex	0.0395988
protein phosphatase type 2A activity	0.0202076
protein serine/threonine phosphatase activity	0.00759448
protein transport	0.0148187
regulation of cyclin-dependent protein kinase activity	0.0395988
regulation of inflammatory response
regulation of progression through cell cycle	0.00000117775
regulation of transcription	0.00833399
regulation of transcription from RNA polymerase II promoter	0.0025796
regulation of viral transcription	0.0202076
response to cold	0.0395988
response to drug	0.0254395
response to freezing	0
response to oxidative stress	0.0189851
response to sterol depletion	0.0395988
response to stimulus	0
retinoic acid metabolic process	0.00774091
retinoic acid receptor signaling pathway	0.0395988
ribonuclease activity	0.0328763
RNA lariat debranching enzyme activity	0.0202076
RNA polymerase II transcription factor activity	0.00614065
RNA splicing	0.0000000131078
selenocysteine incorporation	0.0202076
sensory perception of sound	0.0159483	1
signal transduction	0.00356939	no value
small conjugating protein ligase activity	0
sodium:dicarboxylate symporter activity	0.0127396

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.