MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Gene Enrichment

The table below show, solely based on the number of genes affected in a specific categroy, which classes are enriched (up) or depleted (down). Thje p-value is calculated according to 'GOToolBox: functional analysis of gene datasets based on Gene Ontology - David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry and Bernard Jacq'. We used the mouse-goa annotation from 2005 to perform this analysis.

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p	Ratio	description	Accession	neuronal

Results: HTML CSV LaTeX

Showing element 1 to 50 of 220 in total

neuronal  : no value

p	Ratio	description
0	down	nucleus
	up	cytoplasmic vesicle
		dephosphorylation
		homoiothermy
		ice binding
		membrane
		protein binding
		response to freezing
		response to stimulus
		small conjugating protein ligase activity
1.04188e-19	down	catalytic activity
4.41122e-18		extracellular space
0.00000000000532447	up	cytoplasm
0.0000000000369233	down	receptor activity
0.000000005351	up	cell junction
0.0000000131078		RNA splicing
0.0000000750539		Golgi apparatus
0.000000819712	down	structural constituent of ribosome
0.000000909018		integral to membrane
0.00000117775	up	regulation of progression through cell cycle
0.00000144966	down	nucleic acid binding
0.00000618855		translation
0.00000824263	up	structural constituent of cell wall
0.0000171601		protein kinase activity
0.0000189325		phosphoric monoester hydrolase activity
0.0000244289		cell-cell signaling
0.0000251477	down	ribosome
0.0000321095	up	membrane fraction
0.0000325409	down	G-protein coupled receptor protein signaling pathway
0.0000520983	up	integral to plasma membrane
0.0000603978	down	protein ubiquitination
0.0000791323	up	protein C-terminus binding
0.000237102		nucleocytoplasmic transport
0.00038871	down	external side of plasma membrane
0.000408197	up	flagellin-based flagellum
		mRNA transport
0.000541705	down	ubiquitin ligase complex
0.000654237		zinc ion binding
0.000762333	up	protein dimerization activity
0.000793622		GTPase activity
0.000857538		glycerol metabolic process
0.000975592		transcription
0.00123417	down	ATP binding
0.00127674		antigen binding
0.00141209	up	extracellular region
0.00235127		anion exchanger activity
		arylamine N-acetyltransferase activity
		ciliary or flagellar motility
0.00245746	down	NAD binding
0.0025796	up	positive regulation of transcription

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- Accession is the GO accession key.
- Part of neuralk circuitery.