MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

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Showing element 2351 to 2400 of 2667 in total

Regulation  : up

description	Ratio	Gene Ontology	Class
Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	1.10867	growth hormone secretion	biological process
		growth hormone-releasing hormone activity	molecular function
		growth hormone-releasing hormone receptor binding
		hormone activity
		positive regulation of body size	biological process
		positive regulation of cAMP metabolic process
		positive regulation of growth hormone secretion
		positive regulation of hormone secretion
		positive regulation of transcription
		signal transduction
		terminal button	cellular component
Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]	1.16363	integral to membrane
		membrane
STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]	2.31039	maintenance of protein localization in nucleus	biological process
		nucleus	cellular component
		protein binding	molecular function
		regulation of transcription, DNA-dependent	biological process
		transcription
Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]	3.03423	binding	molecular function
		kinetochore	cellular component
		mitosis	biological process
		regulation of progression through cell cycle
		ubiquitin cycle
		ubiquitin ligase complex	cellular component
T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]	1.33465	cell-cell signaling	biological process
		cytoplasm	cellular component
		embryonic arm morphogenesis	biological process
		embryonic limb morphogenesis
		forelimb morphogenesis
		heart development
		induction of apoptosis
		lung development
		morphogenesis of an epithelium
		multicellular organismal development
		negative regulation of cardiac muscle cell proliferation
		negative regulation of cell migration
		nucleus	cellular component
		pattern specification process	biological process
		pericardium development
		positive regulation of cardioblast differentiation
		positive regulation of transcription from RNA polymerase II promoter
		positive regulation of transcription, DNA-dependent
		protein binding	molecular function
		regulation of transcription, DNA-dependent	biological process
		RNA polymerase II transcription factor activity	molecular function
		sequence-specific DNA binding
		transcription	biological process
		transcription factor activity	molecular function
		transcriptional activator activity
T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	2.86298	brain development	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.