MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

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Showing element 501 to 550 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]	1.25808	biological process	locomotory behavior
			nose development
			palate development
			positive regulation of body size
			regulation of transcription, DNA-dependent
			sensory perception of sound
			transcription
		cellular component	chromatin
			nucleus
		molecular function	ATP binding
			chromatin binding
			DNA binding
			helicase activity
			hydrolase activity
			nucleic acid binding
			nucleotide binding
Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	2.91954	biological process	apoptosis
			response to stress
			RNA splicing
		cellular component	nucleus
		molecular function	DNA binding
			protein binding
CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]	1.86433	biological process	cation transport
			chemotaxis
		cellular component	extracellular space
			integral to membrane
			membrane
		molecular function	ATP binding
			ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
			cytokine activity
Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]	4.05743	biological process	response to stimulus
			sensory perception of sound
			visual perception
		cellular component	integral to membrane
			membrane
Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	1.75026	biological process	axon ensheathment
			calcium-independent cell-cell adhesion
			cell adhesion
			spermatogenesis
		cellular component	cell junction
			integral to membrane
			membrane
			tight junction
		molecular function	identical protein binding
			structural molecule activity
CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]	1.29151	biological process	cell cycle
			cell division
			establishment and/or maintenance of cell polarity
			mitosis
			negative regulation of microtubule depolymerization

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.