MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 688 in total

Class  : cellular component

Ratio	Regulation	description	Gene Ontology
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	integral to membrane
			nucleus
			ribonucleoprotein complex
			U12-dependent spliceosome
1.10233		GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501]	cytoplasm
			cytoskeleton
1.10867		Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	extracellular region
			terminal button
1.10889		Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	cytoplasm
			nucleus
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	integral to plasma membrane
			membrane
			plasma membrane
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	cytoplasm
1.11956	down	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	Golgi apparatus
			integral to Golgi membrane
			integral to membrane
			membrane
1.12417	up	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]
1.1243	down	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	intracellular
			nucleus
1.13007	up	Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]	integral to membrane
			intracellular
			membrane
			nucleus
1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	extracellular region
			membrane
1.14311		14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	cytoplasm
1.14915	up	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]	integral to membrane
			membrane
1.15279		Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	integral to plasma membrane
			membrane
			viral capsid
1.1611	down	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	extracellular region
1.16158	up	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	membrane
1.16363		Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]	integral to membrane
			membrane
1.16393		olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	integral to membrane
1.16499		ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]
			membrane
1.16921		Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]	nucleus
			transcription factor complex
1.17398		Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Uniprot/SWISSPROT;Acc:O75356]	endoplasmic reticulum
			integral to membrane
			membrane
1.17693		Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	cellular_component
			cytoplasm
			membrane
1.17859	down	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	integral to membrane
			membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.