Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1 to 50 of 91 in total
Class: cellular component
Gene Ontology: nucleus

\def\wcA{0.25\textwidth}
\def\wcB{0.25\textwidth}
\def\wcC{0.25\textwidth}
\begin{longtable}{|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Regulation\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
description\vspace{3pt}}\\
\hline
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.07618\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.10889\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.1243\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger protein basonuclin-2. \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.13007\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger protein 219. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.16921\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.18096\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.19117\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Ras-related GTP-binding protein D (Rag D). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.19207\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.19539\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.21384\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Disco-interacting protein 2 homolog C. \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.22047\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.22178\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.22576\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.25113\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.25205\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Protein CWC15 homolog. \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.25808\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.27461\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Homeobox protein Hox-D3 (Hox-4A). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.27696\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.28356\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
T-box transcription factor TBX2 (T-box protein 2). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.28698\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
THO complex subunit 2 (Tho2). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.29952\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.30082\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.30407\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.30869\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.33465\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
T-box transcription factor TBX5 (T-box protein 5). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.35022\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.35125\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Geminin. \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.36755\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Nucleolar preribosomal-associated protein 1 (Fragment). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.37411\vspace{3pt}}&\multirow{6}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Lariat debranching enzyme (EC 3.1.-.-). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.42264\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.44789\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.45148\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.45624\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.45635\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Cyclin-A2 (Cyclin-A). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.48363\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.48389\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.50206\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
LAG1 longevity assurance homolog 4. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.57088\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.59188\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.60746\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.61673\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.65835\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.66679\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.683\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.69345\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.73211\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Antigen KI-67. \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.78439\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.78708\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Centromere protein L (CENP-L) (Interphase centromere complex protein 33). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.81557\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.86204\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). \vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/