MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 51 to 100 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	1.28805	down	cellular component	proteinaceous extracellular matrix
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				peptidase activity
				zinc ion binding
ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	2.45875	up	biological process	proteolysis
			cellular component	extracellular matrix
				intracellular
				proteinaceous extracellular matrix
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				nucleic acid binding
				peptidase activity
				zinc ion binding
Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	5.19755		biological process	fatty acid oxidation
				hormone-mediated signaling
				lipid metabolic process
			cellular component	integral to membrane
				membrane
			molecular function	hormone binding
				identical protein binding
				protein heterodimerization activity
				receptor activity
Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]	1.20924	down	biological process	alcohol metabolic process
				embryonic eye morphogenesis
				lipid metabolic process
				metabolic process
				nucleus accumbens development
				optic cup morphogenesis involved in camera-type eye development
				positive regulation of apoptosis
				retinoic acid metabolic process
			cellular component	cytoplasm
			molecular function	3-chloroallyl aldehyde dehydrogenase activity
				aldehyde dehydrogenase [NAD(P)+] activity
				oxidoreductase activity
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	4.40797		biological process	alcohol metabolic process
				carbohydrate metabolic process
				metabolic process
				neuropeptide signaling pathway
			cellular component	mitochondrion
			molecular function	aldehyde dehydrogenase (NAD) activity
				aldehyde dehydrogenase [NAD(P)+] activity
				electron carrier activity
				neuropeptide hormone activity
				oxidoreductase activity
Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	2.49031	up	biological process	nervous system development
				protein transport
			molecular function	protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.