MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	biological process	ubiquitin cycle
				humoral immune response
				defense response
			cellular component	nucleus
				cytoplasm
			molecular function	translation regulator activity
				oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
				DNA binding
				cofactor binding
				catalytic activity
7.45006	down	MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	biological process	G-protein coupled receptor protein signaling pathway
			cellular component	integral to membrane
			molecular function	structural constituent of cell wall
				histamine receptor activity
7.27043	up	Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]		lipid binding
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	biological process	transcription from RNA polymerase III promoter
				transcription
			cellular component	nucleus
				nucleoplasm
				DNA-directed RNA polymerase III complex
			molecular function	protein binding
				DNA-directed RNA polymerase activity
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	biological process	protein amino acid phosphorylation
			molecular function	transferase activity
				protein-tyrosine kinase activity
				protein serine/threonine kinase activity
				protein kinase activity
				nucleotide binding
				magnesium ion binding
				ATP binding
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	biological process	transcription
				response to stress
				regulation of transcription, DNA-dependent
				negative regulation of cell growth
				intracellular signaling cascade
				apoptosis
			cellular component	nucleus
				cytoplasm
			molecular function	zinc ion binding
				protein binding
				metal ion binding
5.84607		Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	biological process	protein modification process
				protein folding
				microtubule cytoskeleton organization and biogenesis
				beta-tubulin folding
				axonogenesis
			cellular component	microtubule
				cytoskeleton
				cytoplasm
			molecular function	protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.