MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 534 in total

Regulation  : up
Class  : biological process

Ratio	description	Gene Ontology
1.07618	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	G-protein coupled receptor protein signaling pathway
		RNA splicing
1.10233	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501]	cell cycle arrest
1.10831	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	multicellular organismal development
1.10867	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	adenohypophysis development
		cell-cell signaling
		elevation of cytosolic calcium ion concentration
		G-protein signaling, adenylate cyclase activating pathway
		growth hormone secretion
		positive regulation of body size
		positive regulation of cAMP metabolic process
		positive regulation of growth hormone secretion
		positive regulation of hormone secretion
		positive regulation of transcription
		signal transduction
1.10889	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	regulation of transcription, DNA-dependent
		transcription
1.11519	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	translational initiation
1.12417	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	protein homooligomerization
		protein localization
		response to metal ion
1.13007	Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]	anion transport
		G-protein coupled receptor protein signaling pathway
		regulation of transcription, DNA-dependent
1.14915	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]	cell-cell signaling
		signal transduction
		transport
1.15279	Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	cell adhesion
1.16158	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	calcium ion transport
		ion transport
1.16393	olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	G-protein coupled receptor protein signaling pathway
1.16499	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	cell adhesion
		central nervous system development
		negative regulation of cell adhesion
		proteolysis
1.16823	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]	cell proliferation
		G1/S transition of mitotic cell cycle
		regulation of progression through cell cycle
		ubiquitin cycle
1.16921	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]	cell differentiation
		multicellular organismal development
		nervous system development
		regulation of transcription
		regulation of transcription from RNA polymerase II promoter
		regulation of transcription, DNA-dependent
1.17693	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	biological_process
1.17879	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	inner ear morphogenesis
		ion transport
		potassium ion transport
		sensory perception of sound

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.