Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation description Gene Ontology Class Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 151 to 200 of 2667 in total

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\def\wcB{0.16666666666667\textwidth}
\def\wcC{0.16666666666667\textwidth}
\def\wcD{0.16666666666667\textwidth}
\def\wcE{0.16666666666667\textwidth}
\begin{longtable}{|c|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Regulation\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
Gene Ontology\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
Class\vspace{3pt}}\\
\hline
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.16499\vspace{3pt}}&\multirow{31}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
zinc ion binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{1-1}\cline{3-5}
\multirow{5}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.16823\vspace{3pt}}}&&\multirow{5}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell proliferation\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
G1/S transition of mitotic cell cycle\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of progression through cell cycle\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
ubiquitin cycle\vspace{3pt}}&\\\cline{1-1}\cline{3-4}
\multirow{12}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.16921\vspace{3pt}}}&&\multirow{12}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell differentiation\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
DNA binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
multicellular organismal development\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nervous system development\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription from RNA polymerase II promoter\vspace{3pt}}&\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription cofactor activity\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription factor activity\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription factor complex\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription regulator activity\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}\\\cline{1-1}\cline{3-4}
\multirow{7}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.17398\vspace{3pt}}}&&\multirow{7}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
calcium ion binding\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
endoplasmic reticulum\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
hydrolase activity\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
magnesium ion binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleoside-diphosphatase activity\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{1-1}\cline{3-5}
\multirow{6}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.17693\vspace{3pt}}}&&\multirow{6}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
biological\_process\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cellular\_component\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
lipid binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
phosphatidylinositol binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.17859\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
XK-related protein 5. \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}&\\\hline
\multirow{11}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.17879\vspace{3pt}}}&\multirow{11}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{11}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
inner ear morphogenesis\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
ion channel activity\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
ion transport\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane fraction\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
potassium ion binding\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
potassium ion transport\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
sensory perception of sound\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
voltage-gated ion channel activity\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
voltage-gated potassium channel activity\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
voltage-gated potassium channel complex\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\hline
\multirow{6}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.18096\vspace{3pt}}}&\multirow{6}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{6}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
anagen\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
blood pressure regulation\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
caveolar membrane\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cell motility\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cyclooxygenase pathway\vspace{3pt}}&\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/