MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 850 to 899 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.33465	up	T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]	biological process	morphogenesis of an epithelium
				multicellular organismal development
				negative regulation of cardiac muscle cell proliferation
				negative regulation of cell migration
				pattern specification process
				pericardium development
				positive regulation of cardioblast differentiation
				positive regulation of transcription from RNA polymerase II promoter
				positive regulation of transcription, DNA-dependent
				regulation of transcription, DNA-dependent
				transcription
			cellular component	cytoplasm
				nucleus
			molecular function	protein binding
				RNA polymerase II transcription factor activity
				sequence-specific DNA binding
				transcription factor activity
				transcriptional activator activity
1.33817	down	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8]	biological process	autophagic vacuole formation
			cellular component	autophagic vacuole
				cytoplasm
				intracellular
				microtubule
			molecular function	beta-tubulin binding
				GABA receptor binding
				protein binding
1.34001	up	Protein DmX-like 2 (Rabconnectin-3). [Uniprot/SWISSPROT;Acc:Q8TDJ6]	cellular component	cell junction
				cytoplasmic vesicle
				membrane
				synapse
				synaptic vesicle
			molecular function	Rab GTPase binding
1.34491		Bardet-Biedl syndrome 5 protein. [Uniprot/SWISSPROT;Acc:Q8N3I7]	biological process	response to stimulus
				visual perception
			cellular component	cellular_component
				cilium
				intracellular
			molecular function	molecular_function
1.34969		MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Uniprot/SWISSPROT;Acc:P27448]	biological process	protein amino acid phosphorylation
			molecular function	ATP binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
1.35022		N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	biological process	base-excision repair
				DNA repair
				metabolic process
			cellular component	cellular_component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.