MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 1031 in total

Class  : molecular function

Ratio	Regulation	description	Gene Ontology
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	catalytic activity
			cofactor binding
			DNA binding
			oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
			translation regulator activity
7.45006	down	MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	histamine receptor activity
			structural constituent of cell wall
7.27043	up	Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]	lipid binding
6.56408	down	DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	DNA-directed RNA polymerase activity
			protein binding
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	ATP binding
			magnesium ion binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	metal ion binding
			protein binding
			zinc ion binding
5.84607		Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	chaperone binding
			protein binding
5.83544		Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	histone binding
			nucleic acid binding
5.81102	up	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	metal ion binding
			protein binding
			zinc ion binding
5.61927	down	RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	metal ion binding
			nucleoside transporter activity
			protein binding
			zinc ion binding
5.53059	up	rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	GTP binding
			GTPase activity
			heat shock protein binding
			nucleotide binding
			protein binding
5.32612	down	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]
			transcription coactivator activity
			transcription factor activity
5.31521	up	Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]	GTP binding
			nucleotide binding
			protein binding
5.23046	down	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	1-phosphatidylinositol-3-kinase activity
			inositol or phosphatidylinositol kinase activity
			phosphatidylinositol-4,5-bisphosphate 3-kinase activity
			phosphotransferase activity, alcohol group as acceptor
			protein binding
			transferase activity
5.19755	up	Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	hormone binding
			identical protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.