Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 51 to 100 of 103 in total
Class  : molecular function
Gene Ontology  : protein binding
Ratio
Regulation
description
1.66679 up TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]
1.73211 down Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]
1.73291 up BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]
1.76994 down ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]
1.78439 up Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
1.80858 down Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]
1.89308 up Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]
1.93995 Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Uniprot/SWISSPROT;Acc:Q92785]
1.95876 Ras-related protein Rab-17. [Uniprot/SWISSPROT;Acc:Q9H0T7]
1.98137 down Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]
2.07532 up SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]
2.20843 Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]
2.2866 Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]
2.29381 Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]
2.31039 STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]
2.31699 down Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]
2.33107 F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]
2.45764 up zinc transporter like 2 [RefSeq_peptide;Acc:NP_598003]
2.48474 BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]
2.49031 Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]
2.72371 Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]
2.79087 down leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]
2.83611 SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]
2.87038 up Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]
2.91954 Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]
2.93895 down TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]
2.96739 up Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]
3.05037 down Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]
3.21473 up Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma). [Uniprot/SWISSPROT;Acc:P26641]
3.21581 NEDD4-binding protein 2 (EC 3.-.-.-) (N4BP2) (BCL-3-binding protein). [Uniprot/SWISSPROT;Acc:Q86UW6]
3.29064 down Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]
3.36725 up TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]
3.41794 LRRC44 protein. [Uniprot/SPTREMBL;Acc:Q6P5P7]
3.43019 down Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]
3.54414 up Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]
3.54799 down Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]
3.64872 up GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]
3.71868 down Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]
3.81736 up Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
3.99682 down Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]
4.04651 up Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]
4.07995 AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]
4.67988 Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]
4.90535 down DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]
5.23046 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]
5.31521 up Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]
5.32612 down Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]
5.53059 up rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]
5.61927 down RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]
5.81102 up PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/