MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 948 in total

Class  : biological process

Ratio	Regulation	description	Gene Ontology
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	G-protein coupled receptor protein signaling pathway
			RNA splicing
1.10233		GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501]	cell cycle arrest
1.10831		Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	multicellular organismal development
1.10867		Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	adenohypophysis development
			cell-cell signaling
			elevation of cytosolic calcium ion concentration
			G-protein signaling, adenylate cyclase activating pathway
			growth hormone secretion
			positive regulation of body size
			positive regulation of cAMP metabolic process
			positive regulation of growth hormone secretion
			positive regulation of hormone secretion
			positive regulation of transcription
			signal transduction
1.10889		Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	regulation of transcription, DNA-dependent
			transcription
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	neurotransmitter transport
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	translational initiation
1.11956	down	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	retrograde vesicle-mediated transport, Golgi to ER
1.12417	up	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	protein homooligomerization
			protein localization
			response to metal ion
1.1243	down	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	regulation of transcription, DNA-dependent
			transcription
1.13007	up	Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]	anion transport
			G-protein coupled receptor protein signaling pathway
			regulation of transcription, DNA-dependent
1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	blood coagulation
			cell adhesion
			regulation of growth
1.14311		14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	negative regulation of protein kinase activity
			protein targeting
			regulation of neuron differentiation
			regulation of signal transduction
			regulation of synaptic plasticity
1.14915	up	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]	cell-cell signaling
			signal transduction
			transport
1.15279		Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	cell adhesion
1.1611	down	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	electron transport
			signal transduction
1.16158	up	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	calcium ion transport
			ion transport
1.16393		olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	G-protein coupled receptor protein signaling pathway
1.16499		ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	cell adhesion
			central nervous system development
			negative regulation of cell adhesion
			proteolysis
1.16823		S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]	cell proliferation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.