MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.24114	down	cellular component	Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	myosin complex
				striated muscle thick filament
		molecular function		actin binding
				ATP binding
				calmodulin binding
				motor activity
				nucleotide binding
1.24359		biological process	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	exocytosis
				protein transport
		cellular component		cell junction
				cytoplasmic vesicle
				membrane
				synapse
		molecular function		calcium ion binding
				lipid binding
1.24361		biological process	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	metabolic process
				protein amino acid glycosylation
		cellular component		endoplasmic reticulum
				ER-Golgi intermediate compartment
				Golgi apparatus
				integral to membrane
				membrane
				membrane fraction
		molecular function		calcium ion binding
				hydrolase activity, acting on glycosyl bonds
				mannosidase activity
				mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
1.24964		biological process	Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Uniprot/SWISSPROT;Acc:Q8NHH9]	immune response
		cellular component		integral to membrane
				membrane
		molecular function		GTP binding
				GTPase activity
				nucleotide binding
				protein binding
1.25113		biological process	Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). [Uniprot/SWISSPROT;Acc:Q15072]	regulation of transcription, DNA-dependent
		cellular component		intracellular
				nucleus
		molecular function		DNA binding
				heparin binding
				metal ion binding
				nucleic acid binding
				zinc ion binding
1.25147	up	biological process	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]	cell-cell signaling
				immune response
				positive regulation of cell proliferation
				positive regulation of interleukin-2 biosynthetic process
				positive regulation of interleukin-4 biosynthetic process
				positive regulation of lymphotoxin A biosynthetic process
				positive regulation of T-helper 2 cell differentiation
				positive regulation of transcription

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.