MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 1166 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.08658	pyrin and HIN domain family, member 1 alpha 1 isoform [RefSeq_peptide;Acc:NP_689714]	molecular function	protein binding
1.11083	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	biological process	neurotransmitter transport
		cellular component	integral to plasma membrane
			membrane
			plasma membrane
		molecular function	neurotransmitter:sodium symporter activity
			symporter activity
			transporter activity
1.11956	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	biological process	retrograde vesicle-mediated transport, Golgi to ER
		cellular component	Golgi apparatus
			integral to Golgi membrane
			integral to membrane
			membrane
		molecular function	molecular_function
1.1243	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	intracellular
			nucleus
		molecular function	DNA binding
			metal ion binding
			nucleic acid binding
			zinc ion binding
1.13541	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	biological process	blood coagulation
			cell adhesion
			regulation of growth
		cellular component	extracellular region
			membrane
		molecular function	calcium ion binding
			protein binding
			structural molecule activity
			transmembrane receptor activity
1.14311	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	biological process	negative regulation of protein kinase activity
			protein targeting
			regulation of neuron differentiation
			regulation of signal transduction
			regulation of synaptic plasticity
		cellular component	cytoplasm
		molecular function	insulin-like growth factor receptor binding
			protein domain specific binding
			protein kinase C binding
			protein kinase C inhibitor activity
1.1611	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	biological process	electron transport
			signal transduction
		cellular component	extracellular region
		molecular function	electron carrier activity
			enzyme activator activity
			guanylate cyclase activator activity
			hormone activity
1.17859	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]	cellular component	integral to membrane
			membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.