MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	biological process	negative regulation of protein kinase activity
				protein targeting
				regulation of neuron differentiation
				regulation of signal transduction
				regulation of synaptic plasticity
			cellular component	cytoplasm
			molecular function	insulin-like growth factor receptor binding
				protein domain specific binding
				protein kinase C binding
				protein kinase C inhibitor activity
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	2.61135		biological process	DNA damage response, detection of DNA damage
				peptide biosynthetic process
			cellular component	mitochondrial small ribosomal subunit
				mitochondrion
				ribonucleoprotein complex
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	2.16131		biological process	translation
			cellular component	intracellular
				large ribosomal subunit
				mitochondrion
				ribosome
			molecular function	structural constituent of ribosome
40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	2.45383		biological process	translation
			cellular component	cytosolic small ribosomal subunit (sensu Eukaryota)
				intracellular
				ribosome
				small ribosomal subunit
			molecular function	RNA binding
				structural constituent of ribosome
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	1.76994		biological process	cell adhesion
				myoblast fusion
				proteolysis
			cellular component	integral to membrane
				plasma membrane
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				protein binding
				zinc ion binding
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	biological process	cell adhesion
				central nervous system development
				negative regulation of cell adhesion
				proteolysis
			cellular component	integral to membrane
				membrane
			molecular function	integrin binding
				metalloendopeptidase activity
				protein binding
				zinc ion binding
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	1.28805	down	biological process	proteolysis
			cellular component	extracellular matrix

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.