MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 651 to 700 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.28356	down	biological process	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	mammary gland development
				multicellular organismal development
				muscle cell fate determination
				negative regulation of transcription from RNA polymerase II promoter
				positive regulation of cell proliferation
				regulation of transcription, DNA-dependent
				response to freezing
				transcription
				transport
		cellular component		membrane
				nucleus
				transcription factor complex
		molecular function		ice binding
				nucleoside transporter activity
				protein binding
				sequence-specific DNA binding
				transcription factor activity
				transcriptional repressor activity
1.28514	up		EF-hand domain-containing protein C17orf57. [Uniprot/SWISSPROT;Acc:Q8IY85]	calcium ion binding
1.28698		biological process	THO complex subunit 2 (Tho2). [Uniprot/SWISSPROT;Acc:Q8NI27]	mRNA processing
				mRNA transport
				RNA splicing
				transport
		cellular component		nucleus
		molecular function		RNA binding
1.28805	down	biological process	ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	proteolysis
		cellular component		extracellular matrix
				proteinaceous extracellular matrix
		molecular function		metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				peptidase activity
				zinc ion binding
1.29151	up	biological process	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]	cell cycle
				cell division
				establishment and/or maintenance of cell polarity
				mitosis
				negative regulation of microtubule depolymerization
				regulation of microtubule polymerization or depolymerization
		cellular component		cytoplasm
				cytoplasmic microtubule
				cytoskeleton
				Golgi apparatus
				kinetochore microtubule
		molecular function		binding
				galactoside 2-alpha-L-fucosyltransferase activity
				microtubule binding
				microtubule plus-end binding
				protein binding
1.29238			Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]	FAD binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.