MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
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These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 50 of 2667 in total
Gene Ontology
1.07618 up U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696] biological process G-protein coupled receptor protein signaling pathway
RNA splicing
cellular component integral to membrane
ribonucleoprotein complex
U12-dependent spliceosome
molecular function metal ion binding
nucleic acid binding
nucleotide binding
rhodopsin-like receptor activity
RNA binding
zinc ion binding
1.08658 down pyrin and HIN domain family, member 1 alpha 1 isoform [RefSeq_peptide;Acc:NP_689714] protein binding
1.10233 up GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501] biological process cell cycle arrest
cellular component cytoplasm
1.10831 Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113] biological process multicellular organismal development
molecular function collagen binding
1.10867 Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286] biological process adenohypophysis development
cell-cell signaling
elevation of cytosolic calcium ion concentration
G-protein signaling, adenylate cyclase activating pathway
growth hormone secretion
positive regulation of body size
positive regulation of cAMP metabolic process
positive regulation of growth hormone secretion
positive regulation of hormone secretion
positive regulation of transcription
signal transduction
cellular component extracellular region
terminal button
molecular function growth hormone-releasing hormone activity
growth hormone-releasing hormone receptor binding
hormone activity
1.10889 Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24] biological process regulation of transcription, DNA-dependent
cellular component cytoplasm
molecular function protein dimerization activity
sequence-specific DNA binding
transcription factor activity
1.11083 down Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91] biological process neurotransmitter transport
cellular component integral to plasma membrane
plasma membrane
molecular function neurotransmitter:sodium symporter activity
symporter activity
transporter activity
1.11519 up eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408] biological process translational initiation
cellular component cytoplasm

- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.