MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2019 to 2068 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
2.86298	up	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription factor activity	molecular function
2.86538		Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]	cannabinoid receptor activity
			G-protein coupled receptor protein signaling pathway	biological process
			integral to membrane	cellular component
			olfactory receptor activity	molecular function
			receptor activity
			rhodopsin-like receptor activity
			sensory perception of smell	biological process
2.86965		RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]	ATP binding	molecular function
			chromosome	cellular component
			DNA binding	molecular function
			DNA topoisomerase (ATP-hydrolyzing) activity
			DNA topological change	biological process
			nucleic acid binding	molecular function
			nucleotide binding
			nucleus	cellular component
			RNA binding	molecular function
2.87038		Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]	calcium ion binding
			calpain activity
			cysteine-type endopeptidase activity
			cytoplasm	cellular component
			intracellular
			muscle development	biological process
			nucleus	cellular component
			peptidase activity	molecular function
			protein binding
			proteolysis	biological process
			response to calcium ion
			response to drug
			sarcomere organization
			signal transducer activity	molecular function
2.88128	down	CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]	integral to membrane	cellular component
			membrane
			sugar binding	molecular function
2.88235		Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]	anion exchanger activity
			anion transport	biological process
			antiporter activity	molecular function
			inorganic anion exchanger activity
			integral to membrane	cellular component
			integral to plasma membrane
			membrane
			membrane fraction
2.91954	up	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	apoptosis	biological process
			DNA binding	molecular function
			nucleus	cellular component
			protein binding	molecular function
			response to stress	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.