MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 743 to 792 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.86204	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	intracellular
			nucleus
		molecular function	metal ion binding
			nucleic acid binding
			transcription factor activity
			zinc ion binding
1.89168	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]	biological process	lipid metabolic process
			negative regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
			transcription
		cellular component	intracellular
			nucleus
		molecular function	DNA binding
			metal ion binding
			nucleic acid binding
			specific RNA polymerase II transcription factor activity
			transcription factor activity
			zinc ion binding
1.98137	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	biological process	regulation of transcription, DNA-dependent
			signal transduction
			transcription
		cellular component	nucleus
		molecular function	DNA binding
			ligand-dependent nuclear receptor activity
			metal ion binding
			protein binding
			sequence-specific DNA binding
			steroid hormone receptor activity
			thyroid hormone receptor activity
			transcription factor activity
			zinc ion binding
2.08208	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	biological process	hyaluronan metabolic process
		cellular component	extracellular region
		molecular function	serine-type endopeptidase inhibitor activity
2.11557	Echinoderm microtubule-associated protein-like 5 (EMAP-5). [Uniprot/SWISSPROT;Acc:Q05BV3]	cellular component	cytoplasm
			microtubule
2.12709	Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]	biological process	rRNA processing
			tRNA processing
		cellular component	nucleus
			ribonuclease MRP complex
			ribonuclease P complex
		molecular function	hydrolase activity
			identical protein binding
			ribonuclease activity
			ribonuclease P activity
			RNA binding
2.16131	39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	biological process	translation
		cellular component	intracellular

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.