Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1 to 50 of 74 in total
Class: cellular component
Gene Ontology: integral to membrane

\def\wcA{0.25\textwidth}
\def\wcB{0.25\textwidth}
\def\wcC{0.25\textwidth}
\begin{longtable}{|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Regulation\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
description\vspace{3pt}}\\
\hline
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
7.45006\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
MAP7 domain containing 1 \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
5.61927\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
RING finger protein 170 (Putative LAG1-interacting protein). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
5.19755\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
4.67988\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
4.62042\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
4.55371\vspace{3pt}}&\multirow{5}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
4.05743\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Clarin-1 (Usher syndrome type-3 protein). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
4.04651\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
3.89584\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
3.76904\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
3.54928\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
3.52215\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Olfactory receptor 4L1 (Olfactory receptor OR14-28). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
3.41415\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
3.39764\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Junctophilin-1 (Junctophilin type 1) (JP-1). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
3.31364\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
3.14866\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Transmembrane protein 181. \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
3.07625\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
2.88235\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
2.88128\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
2.86538\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
2.85383\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Uncharacterized protein C20orf142 precursor. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
2.79087\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
leucine-rich repeat neuronal 6A \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
2.57202\vspace{3pt}}&\multirow{8}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Protein GPR107 precursor (Lung seven transmembrane receptor 1). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
2.54508\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Neuroligin-2 precursor. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
2.48474\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.98149\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.96673\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.93863\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.86433\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.83601\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
coiled-coil domain containing 90A \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.82063\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Transmembrane protein 116. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.80942\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Uncharacterized protein C18orf26. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.76994\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.75846\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Cystinosin. \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.75026\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Claudin-11 (Oligodendrocyte-specific protein). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.72628\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Coiled-coil domain-containing protein 108. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.69658\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.6384\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Olfactory receptor 6S1. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.63713\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.61987\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.60746\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.60668\vspace{3pt}}&\multirow{6}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.54317\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.50206\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
LAG1 longevity assurance homolog 4. \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.4628\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.45148\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). \vspace{3pt}}\\\cline{1-1}\cline{3-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.40749\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
collagen, type XXVII, alpha 1 \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.40451\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
COX16-like protein C14orf112, mitochondrial precursor. \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.37801\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Glycerophosphodiester phosphodiesterase domain-containing protein 2 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 3) (Osteoblast differentiation promoting factor). \vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.36911\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). \vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/