MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 948 in total

Class  : biological process

Ratio	Regulation	description	Gene Ontology
8.21788	up	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	defense response
			humoral immune response
			ubiquitin cycle
7.45006	down	MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]	G-protein coupled receptor protein signaling pathway
6.56408		DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]	transcription
			transcription from RNA polymerase III promoter
6.50865	up	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	protein amino acid phosphorylation
6.3909	down	Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	apoptosis
			intracellular signaling cascade
			negative regulation of cell growth
			regulation of transcription, DNA-dependent
			response to stress
			transcription
5.84607		Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	axonogenesis
			beta-tubulin folding
			microtubule cytoskeleton organization and biogenesis
			protein folding
			protein modification process
5.83544		Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	chromatin remodeling
			embryonic development
			oocyte differentiation
			positive regulation of meiosis
			regulation of exit from mitosis
			single fertilization
5.61927		RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	transport
5.53059	up	rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	intracellular protein transport
			nucleocytoplasmic transport
			protein transport
			signal transduction
			small GTPase mediated signal transduction
5.32612	down	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]	cellular respiration
			heart development
			inflammatory response
			regulation of transcription
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
5.31521	up	Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]	protein transport
			small GTPase mediated signal transduction
5.23046	down	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	G-protein coupled receptor protein signaling pathway
			negative regulation of apoptosis
			phosphoinositide phosphorylation
			phosphoinositide-mediated signaling
			protein amino acid phosphorylation
5.19755	up	Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	fatty acid oxidation
			hormone-mediated signaling
			lipid metabolic process
5.01332		Ufm1-specific protease 2 (EC 3.4.22.-) (UfSP2). [Uniprot/SWISSPROT;Acc:Q9NUQ7]	ubiquitin cycle
4.93372	down	Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	intracellular signaling cascade
4.71132		Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	glycolysis
			response to other organism

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.