Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1 to 50 of 948 in total
Class: biological process

\def\wcA{0.2\textwidth}
\def\wcB{0.2\textwidth}
\def\wcC{0.2\textwidth}
\def\wcD{0.2\textwidth}
\begin{longtable}{|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Regulation\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
Gene Ontology\vspace{3pt}}\\
\hline
\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.07618\vspace{3pt}}}&\multirow{17}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
G-protein coupled receptor protein signaling pathway\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
RNA splicing\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
1.10233\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell cycle arrest\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
1.10831\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
multicellular organismal development\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{11}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10867\vspace{3pt}}}&&\multirow{11}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
adenohypophysis development\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cell-cell signaling\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
elevation of cytosolic calcium ion concentration\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
G-protein signaling, adenylate cyclase activating pathway\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
growth hormone secretion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of body size\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of cAMP metabolic process\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of growth hormone secretion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of hormone secretion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of transcription\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
signal transduction\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10889\vspace{3pt}}}&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.11083\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
neurotransmitter transport\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.11519\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
translational initiation\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.11956\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Protein RER1. \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
retrograde vesicle-mediated transport, Golgi to ER\vspace{3pt}}\\\hline
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.12417\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
protein homooligomerization\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein localization\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
response to metal ion\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.1243\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger protein basonuclin-2. \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription\vspace{3pt}}\\\hline
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.13007\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger protein 219. \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
anion transport\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
G-protein coupled receptor protein signaling pathway\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}\\\hline
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.13541\vspace{3pt}}}&\multirow{8}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
blood coagulation\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cell adhesion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of growth\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{5}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.14311\vspace{3pt}}}&&\multirow{5}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
negative regulation of protein kinase activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein targeting\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of neuron differentiation\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of signal transduction\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of synaptic plasticity\vspace{3pt}}\\\hline
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.14915\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell-cell signaling\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
signal transduction\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transport\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
1.15279\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
Podocalyxin-like protein 2 precursor (Endoglycan). \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell adhesion\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.1611\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
electron transport\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
signal transduction\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.16158\vspace{3pt}}}&\multirow{8}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
calcium ion transport\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
ion transport\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
1.16393\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
olfactory receptor, family 5, subfamily K, member 4 \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
G-protein coupled receptor protein signaling pathway\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.16499\vspace{3pt}}}&&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell adhesion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
central nervous system development\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
negative regulation of cell adhesion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
proteolysis\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
1.16823\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell proliferation\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/