Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 16 of 16 in total
Class: cellular component
Gene Ontology: integral to plasma membrane
\def\wcA{0.25\textwidth} \def\wcB{0.25\textwidth} \def\wcC{0.25\textwidth} \begin{longtable}{|c|c|c|} \hline \parbox{\wcA}{\vspace{3pt}\noindent Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent Regulation\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent description\vspace{3pt}}\\ \hline \hline \parbox{\wcA}{\vspace{3pt}\noindent 1.11083\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.15279\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Podocalyxin-like protein 2 precursor (Endoglycan). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.30142\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.30802\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.40552\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.42215\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Sodium-dependent serotonin transporter (5HT transporter) (5HTT). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.47697\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.58045\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.61987\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.98149\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 2.8521\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent transient receptor potential cation channel, subfamily M, member 1 \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 2.88235\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 3.48558\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 4.03725\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 4.55371\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 4.62042\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). \vspace{3pt}}\\\hline nd{longtable}
Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

- http://analysis.yellowcouch.org/