Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio description Regulation Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 51 to 100 of 1166 in total

Regulation: down

\def\wcA{0.2\textwidth}
\def\wcB{0.2\textwidth}
\def\wcC{0.2\textwidth}
\def\wcD{0.2\textwidth}
\begin{longtable}{|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Class\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
Gene Ontology\vspace{3pt}}\\
\hline
\hline
\multirow{25}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.18096\vspace{3pt}}}&\multirow{25}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). \vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
anagen\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
blood pressure regulation\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cell motility\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cyclooxygenase pathway\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
electron transport\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
fatty acid biosynthetic process\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
negative regulation of cell proliferation\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of inflammatory response\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of progression through cell cycle\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
response to oxidative stress\vspace{3pt}}\\\cline{3-4}
&&\multirow{7}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
caveolar membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
endoplasmic reticulum\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
microsome\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein complex\vspace{3pt}}\\\cline{3-4}
&&\multirow{10}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
heme binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
iron ion binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
metal ion binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
oxidoreductase activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
peroxidase activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
prostaglandin-endoperoxide synthase activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}\\\cline{1-2}\cline{4-4}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.18141\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein). \vspace{3pt}}}&&\parbox{\wcD}{\vspace{3pt}\noindent
kinase activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transferase activity\vspace{3pt}}\\\hline
\multirow{11}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.18821\vspace{3pt}}}&\multirow{11}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). \vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytokine and chemokine mediated signaling pathway\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
respiratory gaseous exchange\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
signal transduction\vspace{3pt}}\\\cline{3-4}
&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
granulocyte macrophage colony-stimulating factor receptor complex\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{3-4}
&&\multirow{5}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
hematopoietin/interferon-class (D200-domain) cytokine receptor activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
interleukin receptor activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
interleukin-3 receptor activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
interleukin-5 receptor activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
receptor activity\vspace{3pt}}\\\hline
\multirow{12}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.19134\vspace{3pt}}}&\multirow{12}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). \vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell-cell signaling\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
determination of left/right symmetry\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
proteolysis\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
zygotic determination of anterior/posterior axis, embryo\vspace{3pt}}\\\cline{3-4}
&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
endoplasmic reticulum\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
intracellular\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{3-4}
&&\multirow{5}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
calcium ion binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleic acid binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
peptidase activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
subtilase activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
zinc ion binding\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

- http://analysis.yellowcouch.org/