Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio Regulation description Gene Ontology Class Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 451 to 500 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class	
1.22502	up	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Source:Uniprot/SWISSPROT;Acc:Q99758]	transporter activity	molecular function	
1.22528	up	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	dephosphorylation	biological process	
1.22528	up	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	hydrolase activity	molecular function	
1.22528	up	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	phosphoric monoester hydrolase activity	molecular function	
1.22528	up	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	protein amino acid dephosphorylation	biological process	
1.22528	up	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	protein tyrosine phosphatase activity	molecular function	
1.22528	up	protein tyrosine phosphatase domain containing 1 protein isoform 2 [Source:RefSeq_peptide;Acc:NP_818931]	protein tyrosine/serine/threonine phosphatase activity	molecular function	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	DNA binding	molecular function	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	metal ion binding	molecular function	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	methyl-CpG binding	molecular function	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	negative regulation of transcription	biological process	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	nucleus	cellular component	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	protein binding	molecular function	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	regulation of transcription, DNA-dependent	biological process	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	transcription	biological process	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	transcription corepressor activity	molecular function	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	transcription factor activity	molecular function	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	transcription from RNA polymerase II promoter	biological process	
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Source:Uniprot/SWISSPROT;Acc:Q9UIS9]	zinc ion binding	molecular function	
1.22694	up	Protein FAM73B. [Source:Uniprot/SPTREMBL;Acc:Q7L4E1]	type I hypersensitivity	biological process	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	actin binding	molecular function	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	ATP binding	molecular function	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	biological_process	biological process	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	calmodulin binding	molecular function	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	motor activity	molecular function	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	myosin complex	cellular component	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	nucleoside-triphosphatase activity	molecular function	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	nucleotide binding	molecular function	
1.23668	down	Myosin-If (Myosin-Ie). [Source:Uniprot/SWISSPROT;Acc:O00160]	unconventional myosin complex	cellular component	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	cytoplasm	cellular component	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	GTPase activator activity	molecular function	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	intracellular	cellular component	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	metal ion binding	molecular function	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	phosphatidylinositol-3,4,5-triphosphate binding	molecular function	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	regulation of GTPase activity	biological process	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	signal transduction	biological process	
1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Source:Uniprot/SWISSPROT;Acc:Q8WZ64]	zinc ion binding	molecular function	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	cell proliferation	biological process	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	cholesterol metabolic process	biological process	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	endoplasmic reticulum	cellular component	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	integral to membrane	cellular component	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	lipid metabolic process	biological process	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	membrane	cellular component	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	metabolic process	biological process	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	protein binding	molecular function	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	response to sterol depletion	biological process	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	steroid metabolic process	biological process	
1.24114	down	Myosin-15 (Myosin heavy chain 15). [Source:Uniprot/SWISSPROT;Acc:Q9Y2K3]	actin binding	molecular function	
1.24114	down	Myosin-15 (Myosin heavy chain 15). [Source:Uniprot/SWISSPROT;Acc:Q9Y2K3]	ATP binding	molecular function	
1.24114	down	Myosin-15 (Myosin heavy chain 15). [Source:Uniprot/SWISSPROT;Acc:Q9Y2K3]	calmodulin binding	molecular function	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/