Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1 to 50 of 688 in total
Class: cellular component

\def\wcA{0.2\textwidth}
\def\wcB{0.2\textwidth}
\def\wcC{0.2\textwidth}
\def\wcD{0.2\textwidth}
\begin{longtable}{|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Regulation\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
Gene Ontology\vspace{3pt}}\\
\hline
\hline
\multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.07618\vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
ribonucleoprotein complex\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
U12-dependent spliceosome\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10233\vspace{3pt}}}&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cytoskeleton\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10867\vspace{3pt}}}&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
extracellular region\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
terminal button\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10889\vspace{3pt}}}&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\hline
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.11083\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to plasma membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
plasma membrane\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.11519\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\hline
\multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.11956\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Protein RER1. \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
Golgi apparatus\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
integral to Golgi membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}}\\\cline{1-3}
\parbox{\wcA}{\vspace{3pt}\noindent
1.12417\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). \vspace{3pt}}&\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.1243\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger protein basonuclin-2. \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
intracellular\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\hline
\multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.13007\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Zinc finger protein 219. \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
intracellular\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.13541\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
extracellular region\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
1.14311\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.14915\vspace{3pt}}}&\multirow{5}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.15279\vspace{3pt}}}&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Podocalyxin-like protein 2 precursor (Endoglycan). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to plasma membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
viral capsid\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.1611\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
extracellular region\vspace{3pt}}\\\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.16158\vspace{3pt}}&\multirow{14}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 \vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.16363\vspace{3pt}}}&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\parbox{\wcA}{\vspace{3pt}\noindent
1.16393\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent
olfactory receptor, family 5, subfamily K, member 4 \vspace{3pt}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}}\\\cline{1-1}\cline{3-3}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.16499\vspace{3pt}}}&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). \vspace{3pt}}}&\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.16921\vspace{3pt}}}&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription factor complex\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.17398\vspace{3pt}}}&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
endoplasmic reticulum\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{1-1}\cline{3-4}
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.17693\vspace{3pt}}}&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cellular\_component\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.17859\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
XK-related protein 5. \vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/