MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 640 to 689 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.28319	up	Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0]	cytoplasm	cellular component
			intracellular
			positive regulation of protein modification	biological process
			protein amino acid lipidation
			protein binding	molecular function
			protein transport	biological process
			ubiquitin cycle
1.28356	down	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	cardiac muscle development
			cell aging
			heart morphogenesis
			homoiothermy
			ice binding	molecular function
			mammary gland development	biological process
			membrane	cellular component
			multicellular organismal development	biological process
			muscle cell fate determination
			negative regulation of transcription from RNA polymerase II promoter
			nucleoside transporter activity	molecular function
			nucleus	cellular component
			positive regulation of cell proliferation	biological process
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			response to freezing
			sequence-specific DNA binding	molecular function
			transcription	biological process
			transcription factor activity	molecular function
			transcription factor complex	cellular component
			transcriptional repressor activity	molecular function
			transport	biological process
1.28514	up	EF-hand domain-containing protein C17orf57. [Uniprot/SWISSPROT;Acc:Q8IY85]	calcium ion binding	molecular function
1.28698		THO complex subunit 2 (Tho2). [Uniprot/SWISSPROT;Acc:Q8NI27]	mRNA processing	biological process
			mRNA transport
			nucleus	cellular component
			RNA binding	molecular function
			RNA splicing	biological process
			transport
1.28805	down	ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	extracellular matrix	cellular component
			metal ion binding	molecular function
			metalloendopeptidase activity
			metallopeptidase activity
			peptidase activity
			proteinaceous extracellular matrix	cellular component
			proteolysis	biological process
			zinc ion binding	molecular function
1.29151	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]	binding
			cell cycle	biological process
			cell division
			cytoplasm	cellular component
			cytoplasmic microtubule
			cytoskeleton

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.