Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation Ratio description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

Regulation: down

\def\wcA{0.2\textwidth}
\def\wcB{0.2\textwidth}
\def\wcC{0.2\textwidth}
\def\wcD{0.2\textwidth}
\begin{longtable}{|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Class\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
Gene Ontology\vspace{3pt}}\\
\hline
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
1.08658\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
pyrin and HIN domain family, member 1 alpha 1 isoform \vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}\\\hline
\multirow{7}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.11083\vspace{3pt}}}&\multirow{7}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). \vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
neurotransmitter transport\vspace{3pt}}\\\cline{3-4}
&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to plasma membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
plasma membrane\vspace{3pt}}\\\cline{3-4}
&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
neurotransmitter:sodium symporter activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
symporter activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transporter activity\vspace{3pt}}\\\hline
\multirow{6}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.11956\vspace{3pt}}}&\multirow{6}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Protein RER1. \vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
retrograde vesicle-mediated transport, Golgi to ER\vspace{3pt}}\\\cline{3-4}
&&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
Golgi apparatus\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
integral to Golgi membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
molecular\_function\vspace{3pt}}\\\hline
\multirow{8}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.1243\vspace{3pt}}}&\multirow{8}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Zinc finger protein basonuclin-2. \vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription\vspace{3pt}}\\\cline{3-4}
&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
intracellular\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\cline{3-4}
&&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
DNA binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
metal ion binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleic acid binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
zinc ion binding\vspace{3pt}}\\\hline
\multirow{9}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.13541\vspace{3pt}}}&\multirow{9}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). \vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
blood coagulation\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cell adhesion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of growth\vspace{3pt}}\\\cline{3-4}
&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
extracellular region\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{3-4}
&&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
calcium ion binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
structural molecule activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transmembrane receptor activity\vspace{3pt}}\\\hline
\multirow{10}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.14311\vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). \vspace{3pt}}}&\multirow{5}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
negative regulation of protein kinase activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein targeting\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of neuron differentiation\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of signal transduction\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of synaptic plasticity\vspace{3pt}}\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{3-4}
&&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
insulin-like growth factor receptor binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein domain specific binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein kinase C binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein kinase C inhibitor activity\vspace{3pt}}\\\hline
\multirow{7}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.1611\vspace{3pt}}}&\multirow{7}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. \vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
electron transport\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
signal transduction\vspace{3pt}}\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
extracellular region\vspace{3pt}}\\\cline{3-4}
&&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
electron carrier activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
enzyme activator activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
guanylate cyclase activator activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
hormone activity\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.17859\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
XK-related protein 5. \vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

- http://analysis.yellowcouch.org/