MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 368 to 417 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.30207	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]	molecular function	protein binding, bridging
			protein C-terminus binding
			receptor signaling complex scaffold activity
			transport accessory protein activity
1.30802	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438]	biological process	transport
		cellular component	integral to membrane
			integral to plasma membrane
			membrane
			membrane fraction
		molecular function	ATP binding
			ATPase activity
			ATPase activity, coupled to transmembrane movement of substances
			nucleoside-triphosphatase activity
			nucleotide binding
			organic anion transporter activity
			transporter activity
1.30869	E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]	biological process	cell cycle
			cell division
			mitosis
			mitotic cell cycle
			mitotic checkpoint
			protein polyubiquitination
			ubiquitin cycle
			ubiquitin-dependent protein catabolic process
		cellular component	cellular_component
			nucleus
		molecular function	ligase activity
			metal ion binding
			protein binding
			ubiquitin-protein ligase activity
			zinc ion binding
1.31489	Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	cellular component	intracellular
		molecular function	metal ion binding
			protein binding
			zinc ion binding
1.32602	CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]	biological process	protein metabolic process
		molecular function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
1.33817	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8]	biological process	autophagic vacuole formation
		cellular component	autophagic vacuole
			cytoplasm
			intracellular
			microtubule
		molecular function	beta-tubulin binding
			GABA receptor binding
			protein binding
1.351	TBK1 binding protein 1 [RefSeq_peptide;Acc:NP_055541]	biological process	G-protein coupled receptor protein signaling pathway
		cellular component	integral to membrane
		molecular function	dopamine receptor activity
1.36349	Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]	biological process	regulation of progression through cell cycle
			spermatogenesis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.