MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1518 to 1567 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
1.73291	up	protein binding	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	molecular function
		voltage-gated potassium channel activity
		voltage-gated potassium channel complex		cellular component
1.74736	down	cytoplasm	Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]
		membrane
1.75026	up	axon ensheathment	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]	biological process
		calcium-independent cell-cell adhesion
		cell adhesion
		cell junction		cellular component
		identical protein binding		molecular function
		integral to membrane		cellular component
		membrane
		spermatogenesis		biological process
		structural molecule activity		molecular function
		tight junction		cellular component
1.75846	down	amino acid metabolic process	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	biological process
		integral to membrane		cellular component
		L-cystine transport		biological process
		L-cystine transporter activity		molecular function
		lysosomal membrane		cellular component
		lysosome
		membrane
		transport		biological process
1.76583		aminopeptidase activity	leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	molecular function
		antigen processing and presentation of endogenous peptide antigen via MHC class I		biological process
		blood pressure regulation
		endoplasmic reticulum lumen		cellular component
		membrane alanyl aminopeptidase activity		molecular function
		metallopeptidase activity
		N-terminal arginine aminopeptidase activity
		N-terminal lysine aminopeptidase activity
		proteolysis		biological process
		zinc ion binding		molecular function
1.76994		cell adhesion	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	biological process
		integral to membrane		cellular component
		metal ion binding		molecular function
		metalloendopeptidase activity
		metallopeptidase activity
		myoblast fusion		biological process
		plasma membrane		cellular component
		protein binding		molecular function
		proteolysis		biological process
		zinc ion binding		molecular function
1.78439	up	ATP binding	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
		ATP-dependent DNA helicase activity
		ATP-dependent helicase activity
		chromatin		cellular component
		chromatin assembly or disassembly		biological process
		chromatin binding		molecular function
		chromatin modification		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.