Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 100 in total

Class	cellular component
Gene Ontology	membrane

Ratio	Regulation	description	
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	
1.11956	down	Protein RER1. [Source:Uniprot/SWISSPROT;Acc:O15258]	
1.12417	up	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Source:Uniprot/SWISSPROT;Acc:O60888]	
1.13007	up	Zinc finger protein 219. [Source:Uniprot/SWISSPROT;Acc:Q9P2Y4]	
1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Source:Uniprot/SWISSPROT;Acc:Q99435]	
1.14915	up	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Source:Uniprot/SWISSPROT;Acc:Q13445]	
1.15279	up	Podocalyxin-like protein 2 precursor (Endoglycan). [Source:Uniprot/SWISSPROT;Acc:Q9NZ53]	
1.16158	up	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [Source:RefSeq_dna;Acc:NR_002720]	
1.16363	up	Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Source:Uniprot/SWISSPROT;Acc:Q9HBV2]	
1.16499	up	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	
1.17398	up	Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Source:Uniprot/SWISSPROT;Acc:O75356]	
1.17693	up	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Source:Uniprot/SWISSPROT;Acc:Q9H4M7]	
1.17859	down	XK-related protein 5. [Source:Uniprot/SWISSPROT;Acc:Q6UX68]	
1.17879	up	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Source:Uniprot/SWISSPROT;Acc:P56696]	
1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Source:Uniprot/SWISSPROT;Acc:P35354]	
1.18821	down	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Source:Uniprot/SWISSPROT;Acc:P32927]	
1.19134	down	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Source:Uniprot/SWISSPROT;Acc:P29122]	
1.20102	up	Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Source:Uniprot/SWISSPROT;Acc:Q658P3]	
1.20619	down	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Source:Uniprot/SWISSPROT;Acc:Q13733]	
1.21871	down	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Source:Uniprot/SWISSPROT;Acc:Q13323]	
1.23845	down	Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503]	
1.24359	down	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Source:Uniprot/SWISSPROT;Acc:Q86UW7]	
1.24361	down	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Source:Uniprot/SWISSPROT;Acc:P33908]	
1.24964	down	Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Source:Uniprot/SWISSPROT;Acc:Q8NHH9]	
1.25205	down	Protein CWC15 homolog. [Source:Uniprot/SWISSPROT;Acc:Q9P013]	
1.2734	up	Neurexin-2-alpha precursor (Neurexin II-alpha). [Source:Uniprot/SWISSPROT;Acc:Q9P2S2]	
1.28356	down	T-box transcription factor TBX2 (T-box protein 2). [Source:Uniprot/SWISSPROT;Acc:Q13207]	
1.30142	down	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Source:Uniprot/SWISSPROT;Acc:P22607]	
1.30802	down	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Source:Uniprot/SWISSPROT;Acc:O15438]	
1.31661	up	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Source:Uniprot/SWISSPROT;Acc:P40879]	
1.34001	up	Protein DmX-like 2 (Rabconnectin-3). [Source:Uniprot/SWISSPROT;Acc:Q8TDJ6]	
1.36911	down	Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Source:Uniprot/SWISSPROT;Acc:Q96P65]	
1.36997	up	Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Source:Uniprot/SWISSPROT;Acc:Q8N264]	
1.37801	up	Glycerophosphodiester phosphodiesterase domain-containing protein 2 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 3) (Osteoblast differentiation promoting factor). [Source:Uniprot/SWISSPROT;Acc:Q9HCC8]	
1.40451	down	COX16-like protein C14orf112, mitochondrial precursor. [Source:Uniprot/SWISSPROT;Acc:Q9P0S2]	
1.40552	down	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Source:Uniprot/SWISSPROT;Acc:Q9UN76]	
1.42215	down	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Source:Uniprot/SWISSPROT;Acc:P31645]	
1.45148	up	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	
1.47697	up	Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). [Source:Uniprot/SWISSPROT;Acc:P55160]	
1.49264	up	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Source:Uniprot/SWISSPROT;Acc:Q8TAV3]	
1.50206	up	LAG1 longevity assurance homolog 4. [Source:Uniprot/SWISSPROT;Acc:Q9HA82]	
1.50284	down	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Source:Uniprot/SWISSPROT;Acc:P59780]	
1.5415	down	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Source:Uniprot/SWISSPROT;Acc:Q86SQ0]	
1.54317	up	Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Source:Uniprot/SWISSPROT;Acc:Q9Y673]	
1.58045	down	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Source:Uniprot/SWISSPROT;Acc:P56589]	
1.60668	up	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Source:Uniprot/SWISSPROT;Acc:Q9HBA0]	
1.63713	up	Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Source:Uniprot/SWISSPROT;Acc:Q9UH62]	
1.6384	up	Olfactory receptor 6S1. [Source:Uniprot/SWISSPROT;Acc:Q8NH40]	
1.66123	up	KRAB-A domain containing 1 (KRBA1), mRNA [Source:RefSeq_dna;Acc:NM_032534]	
1.69658	down	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Source:Uniprot/SWISSPROT;Acc:Q11206]	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/