MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
3.29064	Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	positive regulation of transcription	biological process
		positive regulation of transcription from RNA polymerase II promoter
		protein binding	molecular function
		regulation of transcription, DNA-dependent	biological process
		RNA polymerase II transcription factor activity, enhancer binding	molecular function
		sequence-specific DNA binding
		transcription	biological process
		transcription factor activity	molecular function
		transcriptional activator activity
		zinc ion binding
3.39764	Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]	biological_process	biological process
		integral to membrane	cellular component
		junctional membrane complex
		membrane
		microsome
		molecular_function	molecular function
		muscle development	biological process
		sarcoplasmic reticulum	cellular component
		structural constituent of muscle	molecular function
		Z disc	cellular component
3.43019	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]	biological_process	biological process
		mRNA processing
		nucleus	cellular component
		protein binding	molecular function
		RNA splicing	biological process
		spliceosome	cellular component
3.48313	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	nucleus
		regulation of transcription, DNA-dependent	biological process
		sequence-specific DNA binding	molecular function
		transcription factor activity
3.52215	Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]	G-protein coupled receptor protein signaling pathway	biological process
		integral to membrane	cellular component
		melanocortin receptor activity	molecular function
		membrane	cellular component
		olfactory receptor activity	molecular function
		receptor activity
		response to stimulus	biological process
		rhodopsin-like receptor activity	molecular function
		sensory perception of smell	biological process
		signal transduction
3.54799	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	calcium channel regulator activity	molecular function
		G-protein coupled receptor protein signaling pathway	biological process
		GTPase activity	molecular function
		protein binding
		signal transducer activity
		signal transduction	biological process
3.54928	Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	cytoplasm	cellular component
		glycerol metabolic process	biological process
		glycerophosphodiester phosphodiesterase activity	molecular function
		hydrolase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.