MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

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Showing element 2619 to 2667 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
5.19755	Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	cellular component	integral to membrane
			membrane
		molecular function	hormone binding
			identical protein binding
			protein heterodimerization activity
			receptor activity
5.31521	Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]	biological process	protein transport
			small GTPase mediated signal transduction
		cellular component	intracellular
		molecular function	GTP binding
			nucleotide binding
			protein binding
5.53059	rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	biological process	intracellular protein transport
			nucleocytoplasmic transport
			protein transport
			signal transduction
			small GTPase mediated signal transduction
		cellular component	intracellular
		molecular function	GTP binding
			GTPase activity
			heat shock protein binding
			nucleotide binding
			protein binding
5.81102	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	cellular component	cell surface
			cytoplasm
			cytoskeleton
			nucleus
		molecular function	metal ion binding
			protein binding
			zinc ion binding
6.50865	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]	biological process	protein amino acid phosphorylation
		molecular function	ATP binding
			magnesium ion binding
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
7.27043	Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]		lipid binding
8.21788	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	biological process	defense response
			humoral immune response
			ubiquitin cycle
		cellular component	cytoplasm
			nucleus
		molecular function	catalytic activity
			cofactor binding
			DNA binding
			oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
			translation regulator activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.