MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 551 to 600 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.49923	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]	protein binding	molecular function
		regulation of small GTPase mediated signal transduction	biological process
		signal transduction
		small GTPase mediated signal transduction
		transmembrane receptor protein tyrosine kinase signaling pathway
1.50284	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	cytoplasmic vesicle	cellular component
		Golgi apparatus
		intracellular protein transport	biological process
		membrane	cellular component
		membrane coat
		protein binding	molecular function
		protein complex assembly	biological process
		protein transporter activity	molecular function
		transport	biological process
		vesicle-mediated transport
1.50715	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]	protein binding	molecular function
		ubiquitin cycle	biological process
1.51342	Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin- antimicrobial peptide 1) (SAP1). [Uniprot/SWISSPROT;Acc:O15263]	chemotaxis
		defense response
		defense response to bacterium
		extracellular region	cellular component
		G-protein coupled receptor protein signaling pathway	biological process
		immune response
1.5415	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]	chloride transport
		cytoplasm	cellular component
		intracellular signaling cascade	biological process
		membrane	cellular component
		phospholipase C activity	molecular function
		signal transduction	biological process
		voltage-gated chloride channel activity	molecular function
1.54676	WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]	actin binding
		actin cytoskeleton	cellular component
		cell adhesion	biological process
		extracellular region	cellular component
		hormone activity	molecular function
		structural molecule activity
1.55809	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H). [Uniprot/SWISSPROT;Acc:Q14442]	cytoplasm	cellular component
		endoplasmic reticulum
		GPI anchor biosynthetic process	biological process
		phosphatidylinositol N-acetylglucosaminyltransferase activity	molecular function
		protein modification process	biological process
		transferase activity, transferring glycosyl groups	molecular function
1.58045	Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]	integral to peroxisomal membrane	cellular component
		integral to plasma membrane
		membrane
		peroxisomal membrane
		peroxisome
		peroxisome organization and biogenesis	biological process
		protein binding	molecular function
1.59763	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	ATP binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.